Overexpression of Colligin 2 in Glioma Vasculature is Associated with Overexpression of Heat shock Factor 2
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چکیده
منابع مشابه
Overexpression of Colligin 2 in Glioma Vasculature is Associated with Overexpression of Heat Shock Factor 2
In previous studies we found expression of the protein colligin 2 (heat shock protein 47 (HSP47), SERPINH1) in glioma neovasculature while not in normal brain tissue. Generally, the regulation of heat shock gene expression in eukaryotes is mediated by heat shock factors (HSF). In mammals, three heat shock transcription factors, HSF-1, -2, and -4, have been isolated. Here we investigated the rel...
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In a previous study using state-of-the-art proteomic techniques, we identified colligin 2 (HSP47) as a glioma blood vessel-specific protein. In the present study we precisely localized the expression of colligin 2 in the blood vessels of diffusely infiltrating gliomas and relate the expression to the distinct cellular components of the vessels by using multiple immunolabeling and confocal micro...
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ژورنال
عنوان ژورنال: Gene Regulation and Systems Biology
سال: 2010
ISSN: 1177-6250,1177-6250
DOI: 10.4137/grsb.s4546